In the aftermath of his father's betrayal, Mark struggles with his responsibilities as Invincible and encounters an unexpected enemy.

It’s summer break for Mark and his friends, but supervillains don't take a vacation. Mark is forced to face the consequences of Omni-Man's double life.

Mark starts his college career, Debbie struggles with personal trauma, and Allen the Alien returns home to find a new threat facing the Coalition of Planets.

Mark answers the call to save an alien species, but the mission has unexpected personal consequences.